Estudo de liberação e permeação in vitro do diclofenaco de dietilamônio em microemulsão gel-like

Química Nova

José Alexsandro Da Silva²  Davi Pereira De Santana¹  Danilo Galindo César Bedor¹  Valeria Ferreira Da Costa Borba¹  Ana Amélia Moreira Lira¹  Eryvaldo Socrates Tabosa Do Egito¹ 

[1] ,Universidade Estadual da Paraíba Departamento de Farmácia Campina Grande PB ,Brasil

关键词: diclofenac diethylamine;    in vitro release;    microemulsion gel-like;   

DOI  :  10.1590/S0100-40422009000600005

来源: SciELO

【 摘 要 】

The goal of this study was to produce and characterize a new microemulsion gel-like carrier system (MEG) by using the pseudo-ternary phase-diagram concept. The diclofenac diethylamine (DDA) was incorporated in the MEG and its in vitro release and permeation profiles were performed using Franz-type diffusion cells. The results revealed that the commercial DDA emulgel provided significantly higher Kp of DDA (2.2-fold) as compared to the MEG. Similar data were obtained in the permeation studies in which DDA Kp 4.7-fold higher. Therefore, MEG presents higher potential as a topical delivery system for DDA when compared to the commercial DDA emulgel.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License