In vitro release and permeation of a diclofenac diethylamine from microemulsion gel-like

Química Nova

Silva, José Alexsandro da¹  Universidade Federal do Rio Grande do Norte, Natal, Brasil¹  Bedor, Danilo Galindo César¹  Lira, Ana Amélia Moreira¹  Universidade Federal de Pernambuco, Recife, Brasil¹  Universidade Federal de Sergipe, São Cristóvão, Brasil¹  Santana, Davi Pereira de¹  Borba, Valeria Ferreira da Costa¹  Egito, Eryvaldo Socrates Tabosa do¹  Universidade Estadual da Paraíba, Campina Grande, Brasil¹ 

关键词: diclofenac diethylamine;    in vitro release;    microemulsion gel-like.;   

DOI  :  10.1590/S0100-40422009000600005

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The goal of this study was to produce and characterize a new microemulsion gel-like carrier system (MEG) by using the pseudo-ternary phase-diagram concept. The diclofenac diethylamine (DDA) was incorporated in the MEG and its in vitro release and permeation profiles were performed using Franz-type diffusion cells. The results revealed that the commercial DDA emulgel provided significantly higher Kp of DDA (2.2-fold) as compared to the MEG. Similar data were obtained in the permeation studies in which DDA Kp 4.7-fold higher. Therefore, MEG presents higher potential as a topical delivery system for DDA when compared to the commercial DDA emulgel.

【 授权许可】

Unknown