Separação cromatográfica quiral de anestésicos a partir de soluções diluídas e concentradas em escala preparativa

Química Nova

Ivanildo José Da Silva Jr.²  Amaro Gomes Barreto Jr.¹  Cesar Costapinto Santana¹ 

[1] ,Universidade Federal do Ceará Campus do PICI Centro de TecnologiaFortaleza CE ,Brasil

关键词: enantiomer separation;    chiral stationary phases;    liquid chromatography;   

DOI  :  10.1590/S0100-40422009000200017

来源: SciELO

【 摘 要 】

In this work the separation of the chiral anesthetic compounds ketamine and bupivacaine was development using two chiral stationary phases (CSP). Ketamine enantiomers were well separate in the polysaccharide-based CSP (microcrystalline cellulose triacetate - MCTA) while bupivacaine in the tartardiamide-based CSP (Kromasil CHI-TBB). In both cases, the effect of temperature was investigated under analytical conditions. An improvement in the separation performance with temperature was observed. Thermodynamic parameters were evaluated by the van't Hoff plot. We concluded that enthalpic effects controlled the retention in these chiral columns. The enantiomers of ketamine and bupivacaine were separated under overloaded conditions with a good performance.

【 授权许可】

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