Síntese de 1-indanonas através da reação de acilação de Friedel-Crafts intramolecular utilizando NbCl5 como ácido de Lewis

Química Nova

Ellen Christine Polo¹  Luiz Carlos Da Silva-filho¹  Gil Valdo José Da Silva¹  Mauricio Gomes Constantino¹ 

[1] ,Universidade de São Paulo Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto Departamento de QuímicaRibeirão Preto SP ,Brasil

关键词: intramolecular Friedel-Crafts acylation reaction;    niobium pentachloride;    synthesis of 1-indanones;   

DOI  :  10.1590/S0100-40422008000400010

来源: SciELO

【 摘 要 】

The intramolecular Friedel-Crafts acylation reaction of 3-arylpropanoic acids to give 1-indanones can be effected in good yields under mild conditions (room temperature) by using niobium pentachloride. Our results indicate that NbCl5 acts both as reagent (to transform carboxylic acids into acyl chlorides) and as catalyst in the Friedel-Crafts cyclization.

【 授权许可】

CC BY-NC   
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