Synthesis of 1-indanones through the intramolecular Friedel-Crafts acylation reaction using NbCl5 as Lewis acid

Química Nova

Silva-Filho, Luiz Carlos da¹  Polo, Ellen Christine¹  Universidade de São Paulo, Ribeirão Preto, Brasil¹  Constantino, Mauricio Gomes¹  Silva, Gil Valdo José da¹ 

关键词: intramolecular Friedel-Crafts acylation reaction;    niobium pentachloride;    synthesis of 1-indanones.;   

DOI  :  10.1590/S0100-40422008000400010

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The intramolecular Friedel-Crafts acylation reaction of 3-arylpropanoic acids to give 1-indanones can be effected in good yields under mild conditions (room temperature) by using niobium pentachloride. Our results indicate that NbCl5 acts both as reagent (to transform carboxylic acids into acyl chlorides) and as catalyst in the Friedel-Crafts cyclization.

【 授权许可】

Unknown