Química Nova | |
Purificação e caracterização da beta-lapachona e estudo de estabilidade dos cristais em diferentes condições de armazenamento | |
Geisiane Maria Cavalcante Alves2  Larissa Araújo Rolim2  Pedro José Rolim Neto2  Ana Cristina Lima Leite2  Dalci José Brondani2  Flávia Patrícia Morais De Medeiros1  Lothar W. Bieber1  Francisco Jaime Bezerra Mendonça Junior1  | |
[1] ,Universidade Federal de Pernambuco Departamento de Ciências Farmacêuticas Recife PE ,Brasil | |
关键词: beta-lapachone; characterization and stability study; | |
DOI : 10.1590/S0100-40422008000200039 | |
来源: SciELO | |
【 摘 要 】
The beta-lapachone is a product obtained from the Ipê Roxo tree [Tabebuia avellandae], which has proved its excellent antineoplasic potential acting through a particular mechanism of apoptosis against various cancer types. This study aims at determining the identity card of beta-lapachone by means of physico-chemical and pharmaco-technical characterization. A purifying process has been performed, as well as the isolation of a contaminant, its isomer alpha-lapachone. A stability study was also performed, determining the ideal storing conditions for beta-lapachone, essential for the ongoing pre-formulation studies for obtaining the different classic pharmaceutical forms and modified release systems.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
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RO202103040062363ZK.pdf | 119KB | download |