Purificação e caracterização da beta-lapachona e estudo de estabilidade dos cristais em diferentes condições de armazenamento

Química Nova

Geisiane Maria Cavalcante Alves²  Larissa Araújo Rolim²  Pedro José Rolim Neto²  Ana Cristina Lima Leite²  Dalci José Brondani²  Flávia Patrícia Morais De Medeiros¹  Lothar W. Bieber¹  Francisco Jaime Bezerra Mendonça Junior¹ 

[1] ,Universidade Federal de Pernambuco Departamento de Ciências Farmacêuticas Recife PE ,Brasil

关键词: beta-lapachone;    characterization and stability study;   

DOI  :  10.1590/S0100-40422008000200039

来源: SciELO

【 摘 要 】

The beta-lapachone is a product obtained from the Ipê Roxo tree [Tabebuia avellandae], which has proved its excellent antineoplasic potential acting through a particular mechanism of apoptosis against various cancer types. This study aims at determining the identity card of beta-lapachone by means of physico-chemical and pharmaco-technical characterization. A purifying process has been performed, as well as the isolation of a contaminant, its isomer alpha-lapachone. A stability study was also performed, determining the ideal storing conditions for beta-lapachone, essential for the ongoing pre-formulation studies for obtaining the different classic pharmaceutical forms and modified release systems.

【 授权许可】

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