期刊论文详细信息
Journal of the Brazilian Chemical Society | |
The preparation of a 10-membered ring macrolactone by selective ozonolysis and the role of the dihydropyran-substituent on the MCPBA-oxidation reaction profile of beta-lapachone phenazines | |
Raphael S. F. Silva2  Tiago T. Guimarães2  Daniel V. Teixeira2  Ana Paula G. Lobato2  Maria Do Carmo F. R. Pinto2  Carlos Alberto De Simone1  Janaína G. Soares1  Alessandra G. Cioletti1  Marilia O. F. Goulart1  Antonio V. Pinto2  | |
[1] ,Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde Núcleo de Pesquisas de Produtos NaturaisRio de Janeiro RJ ,Brazil | |
关键词: beta-lapachone; ozonolysis; 10-membered ring macrolide; selectivity; effect of substituent; | |
DOI : 10.1590/S0103-50532005000600027 | |
来源: SciELO | |
【 摘 要 】
The benzophenazine from beta-lapachone was submitted to ozonolysis under conditions that selectively furnished the corresponding rigid macrocyclic lactone 7,7-dimethyl-7,8,9,10-tetrahydro-5H-benzo[3,4]oxecino[5,6-b]quinoxaline-5,10-dione in an yield of 52%. The effect of substituents located at the dihydropyrane moiety of the phenazines, namely C2'-OH, C2'-Br and C2'-I, in the oxidation with MCPBA, was also investigated.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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