Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina

Química Nova

Renato Grillo²  Nathalie F. S. De Melo²  Leonardo Fernandes Fraceto²  Charles L. Brito¹  Gustavo H. G. Trossini¹  Carla M. S. Menezes¹  Elizabeth Igne Ferreira¹  Carolina Morales Moraes¹ 

[1] ,Universidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental Sorocaba SP ,Brasil

关键词: hydroxymethylnitrofurazone;    cyclodextrin;    inclusion complex;   

DOI  :  10.1590/S0100-40422008000200019

来源: SciELO

【 摘 要 】

Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-beta-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (deltaGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.

【 授权许可】

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