Physico-chemical characterization of inclusion complex between hydroxymethylnitrofurazone and hydroxypropyl-beta-cyclodextrin

Química Nova

Grillo, Renato¹  Melo, Nathalie F. S. de¹  Universidade Estadual Paulista Júlio de Mesquita Filho, Sorocaba, Brasil¹  Universidade de São Paulo, São Paulo, Brasil¹  Ferreira, Elizabeth Igne¹  Moraes, Carolina Morales¹  Fraceto, Leonardo Fernandes¹  Brito, Charles L.¹  Menezes, Carla M. S.¹  Universidade Estadual de Campinas, Campinas, Brasil¹  Trossini, Gustavo H. G.¹ 

关键词: hydroxymethylnitrofurazone;    cyclodextrin;    inclusion complex.;   

DOI  :  10.1590/S0100-40422008000200019

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-b-cyclodextrin (HP-b-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-b-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (DGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.

【 授权许可】

Unknown