Estresse oxidativo, lesões no genoma e processos de sinalização no controle do ciclo celular

Química Nova

Carolina M. Berra²  Carlos F. M. Menck²  Paolo Di Mascio¹ 

[1] ,Universidade de São Paulo Instituto de Ciências Biomédicas Departamento de MicrobiologiaSão Paulo SP ,Brasil

关键词: ATM;    checkpoints;    oxidative stress;   

DOI  :  10.1590/S0100-40422006000600032

来源: SciELO

【 摘 要 】

The generation of reactive oxygen species (ROS) may be both beneficial to cells, performing functions in intracellular signaling and detrimental, modifying cellular biomolecules. ROS can cause DNA damage, such as base damage and strand breaks. Organisms respond to chromosome insults by activation of a complex and hierarchical DNA-damage response pathway. The extent of DNA damages determines cell fate: cell cycle arrest and DNA repair or cell death. The ATM is a central protein in the response to DNA double-strand breaks by acting as a transducer protein. Collected evidences suggest that ATM is also involved in the response to oxidative DNA damage.

【 授权许可】

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