Oxidative stress, genome lesions and signaling pathways in cell cycle control

Quimica nova

Di Mascio, Paolo¹  Berra, Carolina M.¹  Menck, Carlos F. M.¹ 

[1] Universidade de São Paulo, São Paulo, Brasil

关键词: ATM;    checkpoints;    oxidative stress.;   

DOI  :  10.1590/S0100-40422006000600032

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The generation of reactive oxygen species (ROS) may be both beneficial to cells,performing functions in intracellular signaling and detrimental, modifying cellularbiomolecules. ROS can cause DNA damage, such as base damage and strand breaks.Organisms respond to chromosome insults by activation of a complex and hierarchicalDNA-damage response pathway. The extent of DNA damages determines cell fate:cell cycle arrest and DNA repair or cell death. The ATM is a central proteinin the response to DNA double-strand breaks by acting as a transducer protein.Collected evidences suggest that ATM is also involved in the response to oxidativeDNA damage.

【 授权许可】

CC BY