Determinação turbidimétrica de metilbrometo de homatropina em formulações farmacêuticas empregando um sistema de análise por injeção em fluxo

Química Nova

Larissa S. Canaes¹  Orlando Fatibello-filho¹ 

[1] ,Universidade Federal de São Carlos Departamento de Química São Carlos SP ,Brasil

关键词: homatropine methylbromide;    flow injection;    turbidimetry;   

DOI  :  10.1590/S0100-40422006000600017

来源: SciELO

【 摘 要 】

A flow injection turbidimetric procedure exploiting merging zones is proposed for determining homatropine methylbromide (HMB) in pharmaceutical preparations. The determination is based on the precipitation reaction of homatropine methylbromide with AgNO3 solution to form a precipitate, which was measured at 410 nm. The analytical curve was linear in the HMB concentration range from 8.0x10-4 to 1.7x10-3 mol L-1, with a detection limit of 9.5x10-5 mol L-1. The recoveries ranged from 94.9 to 104 %, the sampling frequency was 75 h-1 and relative standard deviations were smaller than 2.0 % for solutions containing 1.2x10-3 and 1.5x10-3 mol L-1 HMB (n=10). The results obtained for commercial formulations using the FIA procedure were in good agreement with those obtained by using a comparative method (r= 0.9983).

【 授权许可】

CC BY-NC   
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