Turbidimetric determination of homatropine methylbromide in pharmaceutical formulations using a flow injection analysis system

Química Nova

Universidade Federal de São Carlos, São Carlos, Brasil¹  Canaes, Larissa S.¹  Fatibello-Filho, Orlando¹ 

关键词: homatropine methylbromide;    flow injection;    turbidimetry.;   

DOI  :  10.1590/S0100-40422006000600017

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A flow injection turbidimetric procedure exploiting merging zones is proposed for determining homatropine methylbromide (HMB) in pharmaceutical preparations. The determination is based on the precipitation reaction of homatropine methylbromide with AgNO3 solution to form a precipitate, which was measured at 410 nm. The analytical curve was linear in the HMB concentration range from 8.0x10-4 to 1.7x10-3 mol L-1, with a detection limit of 9.5x10-5 mol L-1. The recoveries ranged from 94.9 to 104 %, the sampling frequency was 75 h-1 and relative standard deviations were smaller than 2.0 % for solutions containing 1.2x10-3 and 1.5x10-3 mol L-1 HMB (n=10). The results obtained for commercial formulations using the FIA procedure were in good agreement with those obtained by using a comparative method (r= 0.9983).

【 授权许可】

Unknown