Caracterização e estabilidade físico-química de sistemas poliméricos nanoparticulados para administração de fármacos

Química Nova

Scheila Rezende Schaffazick²  Sílvia Stanisçuaski Guterres²  Liane De Lucca Freitas¹  Adriana Raffin Pohlmann¹ 

[1] ,Universidade Federal do Rio Grande do Sul Faculdade de Farmácia Porto Alegre RS

关键词: nanoparticles;    polymers;    characterization;   

DOI  :  10.1590/S0100-40422003000500017

来源: SciELO

【 摘 要 】

Polymeric nanoparticle systems such as nanocapsules and nanospheres present potential applications for the administration of therapeutic molecules. The physico-chemical characteristics of nanoparticle suspensions are important pre-requisites of the success of any dosage form development. The purpose of this review is to present the state of the art regarding the physico-chemical characterization of these drug carriers, in terms of the particle size distribution, the morphology, the polymer molecular weight, the surface charge, the drug content and the in vitro drug release profiles. Part of the review is devoted to the description of the techniques to improve the stability of colloidal systems.

【 授权许可】

CC BY-NC   
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