Physicochemical characterization and stability of the polymeric nanoparticle systems for drug administration

Química Nova

Guterres, Sílvia Stanisçuaski¹  Freitas, Liane de Lucca¹  Schaffazick, Scheila Rezende¹  Pohlmann, Adriana Raffin¹  Universidade Federal do Rio Grande do Sul, Porto Alegre¹ 

关键词: nanoparticles;    polymers;    characterization.;   

DOI  :  10.1590/S0100-40422003000500017

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Polymeric nanoparticle systems such as nanocapsules and nanospheres present potential applications for the administration of therapeutic molecules. The physico-chemical characteristics of nanoparticle suspensions are important pre-requisites of the success of any dosage form development. The purpose of this review is to present the state of the art regarding the physico-chemical characterization of these drug carriers, in terms of the particle size distribution, the morphology, the polymer molecular weight, the surface charge, the drug content and the in vitro drug release profiles. Part of the review is devoted to the description of the techniques to improve the stability of colloidal systems.

【 授权许可】

Unknown