A cascata dos fosfoinositídeos

Química Nova

Mauro Vieira De Almeida¹  Adilson David Da Silva¹  Marcus Vinícius Nora De Souza¹  Aloísio Antônio Alves Benício¹ 

[1] ,Universidade Federal de Juiz de Fora Departamento de Química Juiz de Fora MG

关键词: second messengers;    phosphoinositides;    inositol phosphate;   

DOI  :  10.1590/S0100-40422003000100018

来源: SciELO

【 摘 要 】

Inositol is a polyalcohol required for the proper formation of cell membranes. In the body, its plays an important role in the transmission of nerve impulses, its also helps in the transporting of fats within the body. In mammals, inositol exists as phosphorylated derivatives, various phosphoinositides, and in its free form. Agonist stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is the first step in the transmembrane signalling mechanism when cells respond to external stimuli. Under control of activated phospholipase C (PLC) via G-protein, two second messengers D-myo-inositol 1,4,5-triphosphate [Ins(1,4,5)P3] and diacylglycerol are released into the cell. From Ins(1,4,5)P3, enzymatic process under phosphatases or kinases control affords subsequent inositol phosphate metabolites. During the last decade the synthesis of modified inositol phosphate derivatives has been strongly investigated. This paper reviews principal aspects about synthesis and biological functions of these biomolecules.

【 授权许可】

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