The phosphoinositide cascate

Quimica nova

Almeida, Mauro Vieira de¹  Silva, Adilson David da¹  Souza, Marcus Vinícius Nora de¹  Benício, Aloísio Antônio Alves¹ 

[1] Universidade Federal de Juiz de Fora, Juiz de Fora

关键词: second messengers;    phosphoinositides;    inositol phosphate.;   

DOI  :  10.1590/S0100-40422003000100018

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Inositol is a polyalcohol required for the proper formation of cellmembranes. In the body, its plays an important role in the transmission of nerveimpulses, its also helps in the transporting of fats within the body. In mammals,inositol exists as phosphorylated derivatives, various phosphoinositides, andin its free form. Agonist stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate[PI(4,5)P2] is the first step in the transmembrane signallingmechanism when cells respond to external stimuli. Under control of activatedphospholipase C (PLC) via G-protein, two second messengers D-myo-inositol1,4,5-triphosphate [Ins(1,4,5)P3] and diacylglycerol are releasedinto the cell. From Ins(1,4,5)P3, enzymatic process underphosphatases or kinases control affords subsequent inositol phosphate metabolites.During the last decade the synthesis of modified inositol phosphate derivativeshas been strongly investigated. This paper reviews principal aspects about synthesisand biological functions of these biomolecules.

【 授权许可】

CC BY