Biofilm production by multiresistant Corynebacterium striatumassociated with nosocomial outbreak

Memórias do Instituto Oswaldo Cruz

Cassius De Souza¹  Yuri Vieira Faria¹  Lincoln De Oliveira Sant’anna¹  Vanilda Gonçalves Viana¹  Sérgio Henrique Seabra¹  Mônica Cristina De Souza¹  Verônica Viana Vieira¹  Raphael Hirata Júnior¹  Lílian De Oliveira Moreira¹  Ana Luíza De Mattos-guaraldi¹ 

关键词: biofilm;    Corynebacterium striatum;    epidemic clone;    fibrinogen;    multi-resistance;    nosocomial outbreak;   

DOI  :  10.1590/0074-02760140373

来源: SciELO

【 摘 要 】

Corynebacterium striatum is a potentially pathogenic microorganism that causes nosocomial outbreaks. However, little is known about its virulence factors that may contribute to healthcare-associated infections (HAIs). We investigated the biofilm production on abiotic surfaces of multidrug-resistant (MDR) and multidrug-susceptible (MDS) strains of C. striatum of pulsed-field gel electrophoresis types I-MDR, II-MDR, III-MDS and IV-MDS isolated during a nosocomial outbreak in Rio de Janeiro, Brazil. The results showed that C. striatum was able to adhere to hydrophilic and hydrophobic abiotic surfaces. The C. striatum1987/I-MDR strain, predominantly isolated from patients undergoing endotracheal intubation procedures, showed the greatest ability to adhere to all surfaces. C. striatumbound fibrinogen to its surface, which contributed to biofilm formation. Scanning electron microscopy showed the production of mature biofilms on polyurethane catheters by all pulsotypes. In conclusion, biofilm production may contribute to the establishment of HAIs caused by C. striatum.

【 授权许可】

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