The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms

Memórias do Instituto Oswaldo Cruz

Policarpo Ademar Sales Júnior¹  Celso Oliveira Rezende Júnior¹  Mireille Le Hyaric¹  Mauro Vieira De Almeida¹  Alvaro José Romanha¹ 

关键词: Chagas disease;    Trypanosoma cruzi;    amino alcohols;    diamines;    lipophilicity;   

DOI  :  10.1590/0074-0276130496

来源: SciELO

【 摘 要 】

Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4).

【 授权许可】

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