Preparation and antitubercular activity of lipophilic diamines and amino alcohols

Memórias do Instituto Oswaldo Cruz

Celso Or Júnior²  Mireille Le Hyaric²  Cristiane F Da Costa²  Taís A Corrêa²  Aline F Taveira²  Débora P Araújo²  Elaine Fc Reis²  Maria Cristina S Lourenço¹  Felipe Rc Vicente¹  Mauro V De Almeida¹ 

[1] ,Universidade Federal de Juiz de Fora Departamento de Química Juiz de Fora MG ,Brasil

关键词: tuberculosis;    amino alcohols;    diamines;    lipophilicity;   

DOI  :  10.1590/S0074-02762009000500006

来源: SciELO

【 摘 要 】

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 ¼g/mL.

【 授权许可】

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