Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil

Memórias do Instituto Oswaldo Cruz

Camila Marx¹  Tatiana Schaffer Gregianini¹  Fernanda Kieling Moreira Lehmann¹  Vagner Ricardo Lunge¹  Silvia De Carli¹  Bibiana Paula Dambros¹  Gabriela Luchiari Tumioto¹  Claudete Seadi¹  Andre Salvador Kazantzi Fonseca¹  Nilo Ikuta¹ 

关键词: influenza A(H1N1)pmd09;    resistance;    oseltamivir;   

DOI  :  10.1590/S0074-02762013000300021

来源: SciELO

【 摘 要 】

The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.

【 授权许可】

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