Memórias do Instituto Oswaldo Cruz | |
Cardiomyocyte dysfunction during the chronic phase of Chagas disease | |
Danilo Roman-campos1  Policarpo Sales-júnior1  Hugo Leonardo Duarte1  Eneas Ricardo Gomes1  Silvia Guatimosim1  Catherine Ropert1  Ricardo Tostes Gazzinelli1  Jader Santos Cruz1  | |
关键词: Chagas disease; calcium current; action potential; potassium current; intracellular calcium; Trypanosoma cruzi; | |
DOI : 10.1590/0074-0276108022013019 | |
来源: SciELO | |
【 摘 要 】
Chagas disease, which is caused by the parasite Trypanosoma cruzi, is an important cause of heart failure. We investigated modifications in the cellular electrophysiological and calcium-handling characteristics of an infected mouse heart during the chronic phase of the disease. The patch-clamp technique was used to record action potentials (APs) and L-type Ca2+ and transient outward K+ currents. [Ca2+]i changes were determined using confocal microscopy. Infected ventricular cells showed prolonged APs, reduced transient outward K+ and L-type Ca2+ currents and reduced Ca2+ release from the sarcoplasmic reticulum. Thus, the chronic phase of Chagas disease is characterised by cardiomyocyte dysfunction, which could lead to heart failure.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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RO202103040048371ZK.pdf | 364KB | download |