Cardiomyocyte dysfunction during the chronic phase of Chagas disease

Memórias do Instituto Oswaldo Cruz

Danilo Roman-campos¹  Policarpo Sales-júnior¹  Hugo Leonardo Duarte¹  Eneas Ricardo Gomes¹  Silvia Guatimosim¹  Catherine Ropert¹  Ricardo Tostes Gazzinelli¹  Jader Santos Cruz¹ 

关键词: Chagas disease;    calcium current;    action potential;    potassium current;    intracellular calcium;    Trypanosoma cruzi;   

DOI  :  10.1590/0074-0276108022013019

来源: SciELO

【 摘 要 】

Chagas disease, which is caused by the parasite Trypanosoma cruzi, is an important cause of heart failure. We investigated modifications in the cellular electrophysiological and calcium-handling characteristics of an infected mouse heart during the chronic phase of the disease. The patch-clamp technique was used to record action potentials (APs) and L-type Ca2+ and transient outward K+ currents. [Ca2+]i changes were determined using confocal microscopy. Infected ventricular cells showed prolonged APs, reduced transient outward K+ and L-type Ca2+ currents and reduced Ca2+ release from the sarcoplasmic reticulum. Thus, the chronic phase of Chagas disease is characterised by cardiomyocyte dysfunction, which could lead to heart failure.

【 授权许可】

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