期刊论文详细信息
Memórias do Instituto Oswaldo Cruz
The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates
Débora Alves Nunes Mario2  Laura Bedin Denardi2  Laíssa Arévalo Bandeira2  Milene Silva Antunes1  Janio Morais Santurio2  Luiz Carlos Severo1  Sydney Hartz Alves2 
[1] ,Universidade Federal de Santa Maria Centro de Ciências da Saúde Departamento de Microbiologia e ParasitologiaSanta Maria RS ,Brasil
关键词: Candida glabrata;    echinocandins;    antifungal drug resistance;   
DOI  :  10.1590/S0074-02762012000300022
来源: SciELO
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【 摘 要 】

The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of antifungal agents (azoles, echinocandins and polyenes) against fluconazole-susceptible (FS) and fluconazole-resistant (FR) C. glabrata strains. Cross-resistance between fluconazole and voriconazole was remarkable. Among the antifungal agents, the echinocandins were the most effective against FS and FR C. glabrata and micafungin showed the lowest minimal inhibitory concentrations.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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