The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates

Memórias do Instituto Oswaldo Cruz

Débora Alves Nunes Mario²  Laura Bedin Denardi²  Laíssa Arévalo Bandeira²  Milene Silva Antunes¹  Janio Morais Santurio²  Luiz Carlos Severo¹  Sydney Hartz Alves² 

[1] ,Universidade Federal de Santa Maria Centro de Ciências da Saúde Departamento de Microbiologia e ParasitologiaSanta Maria RS ,Brasil

关键词: Candida glabrata;    echinocandins;    antifungal drug resistance;   

DOI  :  10.1590/S0074-02762012000300022

来源: SciELO

【 摘 要 】

The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of antifungal agents (azoles, echinocandins and polyenes) against fluconazole-susceptible (FS) and fluconazole-resistant (FR) C. glabrata strains. Cross-resistance between fluconazole and voriconazole was remarkable. Among the antifungal agents, the echinocandins were the most effective against FS and FR C. glabrata and micafungin showed the lowest minimal inhibitory concentrations.

【 授权许可】

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