Seroepidemiological study of human parvovirus B19 among human immunodeficiency virus-infected patients in a medium-sized city in Rio de Janeiro, Brazil

Memórias do Instituto Oswaldo Cruz

Kátia Martins Lopes De Azevedo²  Sérgio Setúbal²  Luis Antônio Bastos Camacho¹  Luis Guillermo Coca Velarde¹  Solange Artimos De Oliveira² 

[1] ,Universidade Federal Fluminense Hospital Universitário Antônio Pedro Disciplina de Doenças Infecciosas e ParasitáriasNiterói RJ ,Brasil

关键词: human parvovirus B19;    seroprevalence;    HIV infection;    anaemia;   

DOI  :  10.1590/S0074-02762009000600014

来源: SciELO

【 摘 要 】

Parvovirus B19 (B-19) may cause chronic anaemia in immunosuppressed patients, including those infected with human immunodeficiency virus (HIV). We studied single serum samples from 261 consecutive HIV-infected patients using an enzyme immunoassay to detect IgG antibodies to B-19. The seroprevalence of B-19-IgG was 62.8%. The differences in seroprevalence across gender, age, educational categories, year of collection of the serum samples, clinical and antiretroviral therapy characteristics, CD4+ count, CD4+ and CD8+ percentage and CD4+/CD8+ ratios were neither substantial nor statistically significant. There was a non-significant, inverse association between B-19 seropositivity and plasma HIV load and haemoglobin level. Our results indicated that 37.1% of patients might be susceptible to B-19 infection and remained at risk for being infected, mainly during epidemic periods. As B-19 infection can be treated with immune globulin preparations, it may be included in the diagnostic approach toward chronic anaemia in HIV-infected patients.

【 授权许可】

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