Host immune response to Toxoplasma gondii and Ascaris lumbricoides in a highly endemic area: evidence of parasite co-immunomodulation properties influencing the outcome of both infections

Memórias do Instituto Oswaldo Cruz

Lílian Mg Bahia-oliveira²  Juliana Azevedo Da Silva²  Alba Lucinia Peixoto-rangel²  Marcela Santana Bastos Boechat²  Annelise M Wilken Abreu Oliveira¹  Cristiano L Massara¹  Ricardo Guerra Peixe² 

[1] ,Universidade Estadual do Norte Fluminense Centro de Biociências e Biotecnologia Laboratório de Biologia do ReconhecerCampos dos Goytacazes RJ ,Brasil

关键词: Toxoplasma gondii;    Ascaris lumbricoides;    uveitis;    retinochoroiditis;    environmental contamination;    cytokines;   

DOI  :  10.1590/S0074-02762009000200021

来源: SciELO

【 摘 要 】

Toxoplasmosis and ascaridiasis evoke polar Th-1 and Th-2 host immune responses, respectively. A study to investigate the specific cytokine profile production by in vitro cultures of peripheral blood mononuclear cells from individuals living under precarious sanitary conditions in a highly endemic area for the parasites Toxoplasma gondii and Ascaris lumbricoides was conducted. High levels of both IFN-³ (Th-1) and IL-13 (Th-2) were observed in groups of co-infected individuals presenting toxoplasmic ocular lesions. Significantly lower IL-10 and TGF-² levels were produced by co-infected individuals in comparison with groups of individuals not infected with A. lumbricoides and either positive or negative for T. gondii living under good sanitary conditions (control groups). The possible influence of co-parasitism on the clinical presentation of ocular toxoplasmosis is discussed.

【 授权许可】

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