Antimicrobial resistance among Brazilian Corynebacterium diphtheriae strains

Memórias do Instituto Oswaldo Cruz

Gabriela Andrade Pereira²  Fabrícia Pires Pimenta²  Fátima Rejane Wink Dos Santos¹  Paulo Vieira Damasco¹  Raphael Hirata Júnior²  Ana Luíza Mattos-guaraldi² 

[1] ,Universidade do Estado do Rio de Janeiro Faculdade de Ciências Médicas Disciplina de Microbiologia e ImunologiaRio de Janeiro RJ ,Brasil

关键词: Corynebacterium diphtheriae;    multiresistance;    penicillin;    antibiotics;   

DOI  :  10.1590/S0074-02762008000500019

来源: SciELO

【 摘 要 】

The increasing problems with multidrug resistance in relation to Corynebacterium, including C. diphtheriae, are examples of challenges confronting many countries. For this reason, Brazilian C. diphtheriae strains were evaluated by the E-Test for their susceptibility to nine antibacterial drugs used in therapy. Resistance (MIC < 0.002; 0.38 µg/ml) to penicillin G was found in 14.8% of the strains tested. Although erythromycin (MIC90 0.75 µg/ml) and azithromycin (MIC90 0.064 µg/ml) were active against C. diphtheriae in this study, 4.2% of the strains showed decreased susceptibility (MIC 1.0 µg/ml) to erythromycin. Multiple resistance profiles were determined by the disk diffusion method using 31 antibiotics. Most C. diphtheriae strains (95.74%) showed resistance to mupirocin, aztreonam, ceftazidime, and/or oxacillin, ampicillin, penicillin, tetracycline, clindamycin, lincomycin, and erythromycin. This study presents the antimicrobial susceptibility profiles of Brazilian C. diphtheriae isolates. The data are of value to practitioners, and suggest that some concern exists regarding the use of penicillin.

【 授权许可】

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