Memórias do Instituto Oswaldo Cruz | |
Antimicrobial resistance among Brazilian Corynebacterium diphtheriae strains | |
Gabriela Andrade Pereira2  Fabrícia Pires Pimenta2  Fátima Rejane Wink Dos Santos1  Paulo Vieira Damasco1  Raphael Hirata Júnior2  Ana Luíza Mattos-guaraldi2  | |
[1] ,Universidade do Estado do Rio de Janeiro Faculdade de Ciências Médicas Disciplina de Microbiologia e ImunologiaRio de Janeiro RJ ,Brasil | |
关键词: Corynebacterium diphtheriae; multiresistance; penicillin; antibiotics; | |
DOI : 10.1590/S0074-02762008000500019 | |
来源: SciELO | |
【 摘 要 】
The increasing problems with multidrug resistance in relation to Corynebacterium, including C. diphtheriae, are examples of challenges confronting many countries. For this reason, Brazilian C. diphtheriae strains were evaluated by the E-Test for their susceptibility to nine antibacterial drugs used in therapy. Resistance (MIC < 0.002; 0.38 µg/ml) to penicillin G was found in 14.8% of the strains tested. Although erythromycin (MIC90 0.75 µg/ml) and azithromycin (MIC90 0.064 µg/ml) were active against C. diphtheriae in this study, 4.2% of the strains showed decreased susceptibility (MIC 1.0 µg/ml) to erythromycin. Multiple resistance profiles were determined by the disk diffusion method using 31 antibiotics. Most C. diphtheriae strains (95.74%) showed resistance to mupirocin, aztreonam, ceftazidime, and/or oxacillin, ampicillin, penicillin, tetracycline, clindamycin, lincomycin, and erythromycin. This study presents the antimicrobial susceptibility profiles of Brazilian C. diphtheriae isolates. The data are of value to practitioners, and suggest that some concern exists regarding the use of penicillin.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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RO202005130047437ZK.pdf | 342KB | download |