Antileishmanial and trypanocidal activity of Brazilian Cerrado plants

Memórias do Instituto Oswaldo Cruz

Mariana Laundry De Mesquita²  Julie Desrivot¹  Rib-type="author"> Bories [1] ,Universidade de Brasília Campus Universitário Darcy Ribeiro Faculdade de Ciências da SaúdeBrasília, DF,Brasil

关键词: Brazilian Cerrado plants;    leishmaniasis;    Chagas disease;    Leishmania donovani;    Trypanosoma cruzi;    Brazil;   

DOI  :  10.1590/S0074-02762005000700019

来源: SciELO

【 摘 要 】

The side effects and the emerging resistance to the available drugs against leishmaniasis and trypanosomiasis led to the urgent need for new therapeutic agents against these diseases. Thirty one extracts of thirteen medicinal plants from the Brazilian Cerrado were therefore evaluated in vitro for their antiprotozoal activity against promastigotes of Leishmania donovani, and amastigotes of Trypanosoma cruzi. Among the selected plants, Casearia sylvestris var. lingua was the most active against both L. donovani and T. cruzi. Fifteen extracts were active against promastigotes of L. donovani with concentrations inhibiting 50% of parasite growth (IC50) between 0.1-10 µg/ml, particularly those of Annona crassiflora (Annonaceae), Himatanthus obovatus (Apocynaceae), Guarea kunthiana (Meliaceae), Cupania vernalis (Sapindaceae), and Serjania lethalis (Sapindaceae). With regard to amastigotes of T. cruzi, extracts of A. crassiflora, Duguetia furfuracea (Annonaceae), and C. sylvestris var. lingua were active with IC50 values between 0.3-10 µg/ml. Bioassay fractionations of the more active extracts are under progress to identify the active antiparasite compounds.

【 授权许可】

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