Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological

Molecules

WendyMarina Toscano Queiroz de Medeiros¹  MarceloSousa Silva¹  JohnyWysllas de Freitas Oliveira¹  HugoAlexandre Oliveira Rocha² 

[1] Laboratório de Imunoparasitologia, Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil;Programa de Pós-graduação em Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil;

关键词: dithiocarbamates;    DETC;    antiparasitic activity;    Trypanosomatids;    Chagas disease;    leishmaniasis;    African trypanosomiasis;   

DOI  :  10.3390/molecules24152806

来源: DOAJ

【 摘 要 】

Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.

【 授权许可】

Unknown