Genetic characterization of Trypanosoma cruzi natural clones from the state of Paraíba, Brazil

Memórias do Instituto Oswaldo Cruz

Christian Barnabé²  M Tibayrenc²  Carlos Brisola Marcondes¹ 

[1] ,Institut de Recherche pour le Développement Unité Mixte de Recherche Centre National de la Recherche Scientifique Génétique et Evolution des Maladies Infectieuses,France

关键词: Trypanosoma cruzi;    Triatoma pseudomaculata;    Triatoma brasiliensis;    Didelphis albiventris;    multilocus enzyme electrophoresis;    random primed amplified polymorphic DNA;    Chagas disease;    Paraíba;    Brazil;   

DOI  :  10.1590/S0074-02762005000300010

来源: SciELO

【 摘 要 】

Eighteen Trypanosoma cruzi stocks from the state of Paraíba, Brazil, isolated from man, wild mammals, and triatomine bugs were studied by multilocus enzyme electrophoresis and random primed amplified polymorphic DNA. Despite the low number of stocks, a notable genetic, genotypic, and phylogenetic diversity was recorded. The presence of the two main phylogenetic subdivisions, T. cruzi I and II, was recorded. The strong linkage disequilibrium observed in the population under survey suggests that T. cruzi undergoes predominant clonal evolution in this area too, although this result should be confirmed by a broader sample. The pattern of clonal variation does not suggests a recent origin by founder effect with a limited number of different genotypes.

【 授权许可】

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