The association of genetic markers and malaria infection in the Brazilian Western Amazonian region

Memórias do Instituto Oswaldo Cruz

B Beiguelman²  Fp Alves²  Mm Moura¹  V Engracia¹  Acs Nunes¹  Mio Heckmann¹  Rgm Ferreira²  Lh Pereira Da Silva¹  Ep Camargo²  H Krieger² 

[1] ,Universidade de São Paulo Instituto de Ciências Biomédicas Departamento de ParasitologiaSão Paulo SP ,Brasil

关键词: malaria;    genetic markers;    association studies;    Western Amazonia;    Rondônia;    Brazil;   

DOI  :  10.1590/S0074-02762003000400004

来源: SciELO

【 摘 要 】

Almost all individuals (182) belonging to an Amazonian riverine population (Portuchuelo, RO, Brazil) were investigated for ascertaining data on epidemiological aspects of malaria. Thirteen genetic blood polymorphisms were investigated (ABO, MNSs, Rh, Kell, and Duffy systems, haptoglobins, hemoglobins, and the enzymes glucose-6-phosphate dehydrogenase, glyoxalase, phosphoglucomutase, carbonic anhydrase, red cell acid phosphatase, and esterase D). The results indicated that the Duffy system is associated with susceptibility to malaria, as observed in other endemic areas. Moreover, suggestions also arose indicating that the EsD and Rh loci may be significantly associated with resistance to malaria. If statistical type II errors and sample stratification could be ruled out, hypotheses on the existence of a causal mechanism or an unknown closely linked locus involved in susceptibility to malaria infection may explain the present findings.

【 授权许可】

CC BY   
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