Morphometry of submucous and myenteric esophagic plexus of dogs experimentally reinfected with Trypanosoma cruzi

Memórias do Instituto Oswaldo Cruz

Evandro Mm Machado²  Deolino J Camilo Júnior¹  Simone W Pinheiro¹  Edison Reis Lopes¹  Alexandre J Fernandes²  João Carlos Pinto Dias²  Sheila J Adad¹ 

[1] ,Fiocruz Centro de Pesquisas René Rachou Belo Horizonte MG ,Brasil

关键词: Chagas disease;    Trypanosoma cruzi;    dog;    reinfection;    esophagus;    myenteric plexus;   

DOI  :  10.1590/S0074-02762001000400017

来源: SciELO

【 摘 要 】

We carried out a morphometric study of the esophagus of cross-bred dogs experimentally infected or consecutively reinfected with Trypanosoma cruzi 147 and SC-1 strains, in order to verify denervation and/or neuronal hypertrophy in the intramural plexus. The animals were sacrificed in the chronic stage, 38 months after the initial infection. Neither nests of amastigotes, nor myositis or ganglionitis, were observed in all third inferior portions of esophageal rings analyzed. No nerve cell was identified in the submucous of this organ. There was no significant difference (p>0.05) between the number, maximum diameter, perimeter, or area and volume of the nerve cells of the myenteric plexus of infected and/or reinfected dogs and of the non-infected ones. In view of these results we may conclude that the 147 and SC-1 strains have little neurotropism and do not determine denervation and/or hypertrophy in the intramural esophageal plexuses in the animals studied, independent of the reinfections.

【 授权许可】

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