Genitourinary changes in hamsters infected and reinfected with Trypanosoma cruzi

Memórias do Instituto Oswaldo Cruz

Marlene Cabrine-santos¹  Vitorino Modesto Dos Santos¹  Marcus Aurelho De Lima¹  Marta Elena Araújo De Abreu¹  Eliane Lages-silva¹  Luís Eduardo Ramírez¹ 

[1] ,Faculdade de Medicina do Triângulo Mineiro Departamento de Clínica Médica, Uberaba MG ,Brasil

关键词: hamsters;    Trypanosoma cruzi;    reinfection;    testis;    Chagas disease;   

DOI  :  10.1590/S0074-02762003000400018

来源: SciELO

【 摘 要 】

Authors describe genitourinary changes in male hamsters infected and reinfected with Trypanosoma cruzi. Changes in genital organs have been described in human and in experimental chagasic infection. Genital dysfunctions in chronic chagasic patients affect ejaculation, libido and sexual potency, and testis biopsies may show arrested maturation of germ cells, oligozoospermia and azoospermia. Sixty-five male hamsters were inoculated and reinoculated with 2x10³ trypomastigotes of T. cruzi VIC strain, and 22 non-infected animals constituted the control group. Animals were necropsied and fragments from testis, epididymis, seminal vesicle and bladder were collected and stained with hematoxylin-eosin. Peroxidase anti-peroxidase procedure was utilized to detect tissue parasitism. T. cruzi nests were found in testis, epididymis and seminal vesicle of these hamsters. Such parasitism plays a role in the origin of genital lesions observed in humans and laboratory animals during chronic chagasic infection.

【 授权许可】

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