Trypanosoma cruzi-cardiomyocytes: new contributions regarding a better understanding of this interaction

Memórias do Instituto Oswaldo Cruz

Maria De Nazareth Leal De Meirelles²  Mirian Claudia S Pereira²  Robert H Singer¹  Maria De Nazaré C Soeiro²  Luciana R Garzoni²  Dayse T Silva²  Helene S Barbosa²  Tania C Araujo-jorge²  Masako O Masuda¹  Marcia Am Capella¹  Anibal Gil Lopes¹  Alane B Vermelho¹ 

[1] ,Instituto Oswaldo CruzRio de Janeiro RJ ,Brasil

关键词: Trypanosoma cruzi;    cardiomyocytes;    calcium;    SERCA ATPases;    mRNA regulation;   

DOI  :  10.1590/S0074-02761999000700017

来源: SciELO

【 摘 要 】

The present paper summarizes new approaches regarding the progress done to the understanding of the interaction of Trypanosoma cruzi-cardiomyocytes. Mannose receptors localized at the surface of heart muscle cell are involved in binding and uptake of the parasite. One of the most striking events in the parasite-heart muscle cells interaction is the disruption of the actin cytoskeleton. We have investigated the regulation of the actin mRNA during the cytopathology induced in myocardial cells by the parasite. T. cruzi invasion increases calcium resting levels in cardiomyocytes. We have previously shown that Ca2+ ATPase of the sarcoplasmic reticulum (SERCA) is involved in the invasion of T. cruzi in cardiomyocytes. Treating the cells with thapsigargin, a drug that binds to all SERCA ATPases and causes depletion of intracellular calcium stores, we found a 75% inhibition in the T. cruzi-cardiomyocytes invasion.

【 授权许可】

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