Involvement of regional lymph nodes after penetration of Schistosoma mansoni cercariae in naive and infected mice

Memórias do Instituto Oswaldo Cruz

Silene P Lozzi¹  Conceição Rs Machado¹  Silvia E Gerken¹  Tomas A Mota-santos² 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Biológicas Belo Horizonte MG ,Brasil

关键词: Schistosoma mansoni;    lymph nodes;    schistosomulum migration;    eosinophils;    mast cells;    high endothelial venules;   

DOI  :  10.1590/S0074-02761996000400017

来源: SciELO

【 摘 要 】

The parotid lymph nodes of naive and previously infected Balb/c mice were studied after, respectively, infection and re-infection with cercariae of Schistosoma mansoni via the ears. Schistosomula were able to pass through the lymph node by following the lymph flow or by penetrating the veins of the medullary cords. The number of nodal mast cells was higher from day 2 to 6 of primary infection; and from day 5 to 11 of re-infection. The amount of degranulating mast cells was significantly higher at day 4 of infection and at day 1 of re-infection. Eosinophils characterized the nodal inflammatory processes observed after day 5 in both primarily-infected and re-infected mice. However, only in the latter the eosinophils were able to adhere to the larval surface. In primarily-infected mice, no intranodal larva presented signs of degeneration. In contrast, in re-infected animals, some degenerating larvae were found inside eosinophilic infiltrates. The eosinophils reached the nodal tissue by migrating through the high endothelial venules and their collecting veins.

【 授权许可】

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