Extramedullary hematopoiesis in murine schistosomiasis mansoni

Memórias do Instituto Oswaldo Cruz

H. L. Lenzi¹  J. A. Lenzi¹  F. C. Rosman¹  M. Pelajo-machado¹  E. M. Mota¹  M. S. Panasco¹  D. N. Oliveira¹ 

[1] ,Instituto Oswaldo Cruz Departamento de Patologia Rio de Janeiro,Brasil

关键词: cosinophil;    neutrophil;    megakaryocyte;    hematopoiesis;    Schistosoma mansoni;    lymph nodes;    milky spots;   

DOI  :  10.1590/S0074-02761995000200008

来源: SciELO

【 摘 要 】

During Schistosoma mansoni infection, there is morphological evidence of involvement of various hematopoietic growth factors, which cause eosinophil, neutrophil, megakaryocytic and erythroid extramedullary foci in the liver, lymph nodes and omental and mesenteric milky spots. While the eosinophil metaplasia in the periphery of hepatic granulomas roughly reproduced the intensity of the medullary eosinopoiesis, the neutrophil metaplasia, on the contrary, was more intense during the period of neutrophil depression in the bone marrow. This fact suggests that extramedullary hematopoietic foci are locally regulated, and amplify and/or compensate the systemic hematopoietic response during the infection.

【 授权许可】

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