Biological comparison between three clones of Trypanosoma cruzi and the strain of origin (Bolivia) with reference to clonal evolution studies

Memórias do Instituto Oswaldo Cruz

P Penin²  C Gamallo¹  Ja De Diego¹ 

[1] ,Universidad Autónoma de Madrid Departamento de Medicina Preventiva y Salud Pública Unidad de Parasitología y Medicina TropicalMadrid,España

关键词: Trypanosoma cruzi;    histopathological study;    clonal variability;    biological characterization;   

DOI  :  10.1590/S0074-02761996000300006

来源: SciELO

【 摘 要 】

After isolating three clones of Trypanasoma cruzi (Bolivia), we first characterized them according to parasitaemia, pleomorphism and virulence, and then histopathologically. The study's interest lies on the hypothesis that clonal evolution of T. cruzi has a major impact on biologically relevant properties of this parasite. Data obtained from the studies of parasitaemia, pleomorphism and virulence showed no differences between the groups studied. As a final point, the histopathological study shows us a muscular tissue tropism both in clones and in their mother strain (Bolivia). In this paper, we conclude that Bolivia strain and clones isolated from it, pertaining to the same major clone share similar biological properties.

【 授权许可】

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