Morphological and virological studies in six autopsies of children with adenovirus pneumonia

Memórias do Instituto Oswaldo Cruz

A. G. P. Garcia¹  M. E. F. Fonseca²  M. De Bonis²  H. I. B. Ramos¹  Z. P. A. Ferro¹  J. P. Nascimento² 

[1] ,FIOCRUZ Instituto Fernandes Figueira Departamento de Anatomia PatológicaRio de Janeiro,Brasil

关键词: adenovirus infection;    viral pneumonia;    childhood pneumonia;   

DOI  :  10.1590/S0074-02761993000100022

来源: SciELO

【 摘 要 】

Pulmonary lesions compatible with adenovirus infection were detected by gross and microscopic examination of autopsy tissues children aged from 5 to 34 months. Hepatic lesions indicative of systemic infection were also found in four of the chisldren. The viral etiology was confirmed in three cases by in-situ hibridization, electro-microscopy and immunofluorescence performed in parafin-embedded tissues, and in one case by cell culture isolation of adenovirus type 2 from nasopharyngeal exudate. Routine testing by methods additional to conventional light microscopy would probably have revealed a larger number of adenovirus infections among the 1.103 autopsy records analyzed in this study.

【 授权许可】

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