Autoradiographic analysis of Schistosoma mansoni migration in the NZ rabbit

Memórias do Instituto Oswaldo Cruz

R. Magalhães Pinto¹  Marília S. A. Almeida²  Dely Noronha¹  Naftale Katz¹  Miriam Tendler¹ 

[1] ,Instituto Oswaldo Cruz Departamento de Helmintologia Rio de Janeiro,Brasil

关键词: Schistosoma mansoni;    migration;    autoradiographic analysis;    rabbit model;   

DOI  :  10.1590/S0074-02761990000100015

来源: SciELO

【 摘 要 】

The migration of larval Schistosoma mansoni was tracked by means of autoradiographic analysis in naive rabbits percutaneously exposed to L-(**75 Se) selenomethionine-labeled cercariae on serial intervals of 1, 2, 4, 6, 8, 10, 15, 20, 25, 30, 40 and 50 days post-infection. Autoradiographic foci were detected from the 1st day in the skin, up to the 15th day in the liver. Adult and mature worms were recovered either paired or not 60 days after infection, by perfusion of hepatic and mesenteric veins. Morphometric analysis under optical microscopy, showed that worms were within regular dimention limits as compared to adult worms harboured by other host species. These observations extend previous informations on the S. mansoni-rabbit association and clearly demonstrate the post-liver phase of S.mansoni life-cycle in this host.

【 授权许可】

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