Acta Amazonica | |
In vitro studies of the anthelmintic activity of Picrolemma sprucei Hook. f. (Simaroubaceae) | |
Rita De Cássia Saraiva Nunomura2  Ellen Cristina Costa Da Silva2  Denilson Ferreira Oliveira1  Adriana Mello Garcia1  Jankerle Neves Boeloni1  Sergio Massayoshi Nunomura1  Adrian Martin Pohlit2  | |
[1] ,Universidade Federal do Amazonas Instituto de Ciências Exatas Departamento de QuímicaManaus Amazonas ,Brazil | |
关键词: Picrolemma pseudocoffea Ducke; Haemonchus contortus; neosergeolide; isobrucein B; caferana; Picrolemma pseudocoffea Ducke; Haemonchus contortus; neosergeolida; isobruceína; caferana; | |
DOI : 10.1590/S0044-59672006000300006 | |
来源: SciELO | |
【 摘 要 】
1300 ppm (1.3 g / L), water and ethanol extracts prepared from stems or roots of Picrolemma sprucei Hook. f. were lethal (85-90 % mortality) in vitro to Haemonchus contortus (Barber Pole Worm) larvae, a gastrointestinal nematode parasite found in domestic and wild ruminants. Neosergeolide and isobrucein B were isolated in 0.0083 and 0.0070 % yield from dry, ground P. sprucei stems (0.89 kg). Neosergeolide, isobrucein B and the anthelmintic drug standard levamisole all caused comparable mortality rates (68-77 %) in vitro to H. contortus at similar concentrations (81-86 ppm). The anthelmintic activity of P. sprucei infusions (teas), alcohol extracts, and neosergeolide and isobrucein B, has therefore been demonstrated for the first time.
【 授权许可】
CC BY
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