In vitro studies of the anthelmintic activity of Picrolemma sprucei Hook. f. (Simaroubaceae)

Acta Amazonica

Rita De Cássia Saraiva Nunomura²  Ellen Cristina Costa Da Silva²  Denilson Ferreira Oliveira¹  Adriana Mello Garcia¹  Jankerle Neves Boeloni¹  Sergio Massayoshi Nunomura¹  Adrian Martin Pohlit² 

[1] ,Universidade Federal do Amazonas Instituto de Ciências Exatas Departamento de QuímicaManaus Amazonas ,Brazil

关键词: Picrolemma pseudocoffea Ducke;    Haemonchus contortus;    neosergeolide;    isobrucein B;    caferana;    Picrolemma pseudocoffea Ducke;    Haemonchus contortus;    neosergeolida;    isobruceína;    caferana;   

DOI  :  10.1590/S0044-59672006000300006

来源: SciELO

【 摘 要 】

1300 ppm (1.3 g / L), water and ethanol extracts prepared from stems or roots of Picrolemma sprucei Hook. f. were lethal (85-90 % mortality) in vitro to Haemonchus contortus (Barber Pole Worm) larvae, a gastrointestinal nematode parasite found in domestic and wild ruminants. Neosergeolide and isobrucein B were isolated in 0.0083 and 0.0070 % yield from dry, ground P. sprucei stems (0.89 kg). Neosergeolide, isobrucein B and the anthelmintic drug standard levamisole all caused comparable mortality rates (68-77 %) in vitro to H. contortus at similar concentrations (81-86 ppm). The anthelmintic activity of P. sprucei infusions (teas), alcohol extracts, and neosergeolide and isobrucein B, has therefore been demonstrated for the first time.

【 授权许可】

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