Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection

Revista da Sociedade Brasileira de Medicina Tropical

Amanda Alves Fecury¹  Marcella Kelly Costa De Almeida¹  Kemper Nunes Dos Santos¹  Andrei Da Silva Freitas¹  Socorro De Fátima Loureiro Dantas¹  Carlos Araújo Da Costa¹  Ângelo Barlleta Crescente¹  Rita Catarina Medeiros De Sousa¹  Elza Baía De Brito¹  Reza Nassiri¹  Elizabeth Lampe¹  Luisa Caricio Martins¹ 

关键词: Hepatitis C virus;    Genotype;    Histopathology;   

DOI  :  10.1590/0037-8682-0008-2012

来源: SciELO

【 摘 要 】

Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction.

【 授权许可】

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