Base transitions and base transversions seen in mutations among various types of the hepatitis C viral genome

FEBS Letters

Shimotohno, Kunitada¹  Hijikata, Makoto¹  Tanaka, Torahiko¹  Kato, Nobuyuki¹ 

[1] Virology Division, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104, Japan

关键词: Hepatitis C virus;    Genotype;    Mutation;    Base transition;    Base transversion;    Multiple base substitution;   

DOI  :  10.1016/0014-5793(93)81163-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We counted base transitions (Ts) and transversions (Tv) in mutations among various types of hepatitis C virus (HCV) sequences. The Ts/TV ratio was useful for distinguishing the (geno)type of the compared HCV sequences, since the ratio was 4.0 or more among sequences of the same type, while it was less than 2.0 among sequences of different types. This observation reflects the evolutionary pathway of HCV in which tv accumulate among distant genomes by mechanisms including multiple base substitutions.

【 授权许可】

Unknown