Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters

Revista da Sociedade Brasileira de Medicina Tropical

Silva, Maria Betânia Souza da¹  Santana, Aurelino¹  Costa, Fernando Quadros¹  Fundação Oswaldo Cruz, Salvador, Brazil¹  Reis, Mitermayer Galvão dos¹  Silva, Luciano Kalabric¹  FDC, Salvador, Brazil¹  Rodart, Itatiana Ferreira¹  Secretaria de Saúde do Estado da Bahia, Salvador, Brazil¹  Universidade Federal da Bahia, Salvador, Brazil¹  Paraná, Raymundo¹  Santana, Nelma P.¹  Lopes, Gisele Barreto¹ 

关键词: Hepatitis C virus;    Hemophilia;    Prevalence;    Genotype;    Bahia;   

DOI  :  10.1590/S0037-86822005000600010

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The objective of the present study was to analyze HCV serological and virological parameters from hemophiliacs in the State of Bahia. Anti-HCV was investigated by ELISA in a cohort of 268 hemophiliacs A/B who were followed-up in a reference unit for hemotherapy in the State of Bahia. HCV viremia and genotypes were also determined from a subset of 66 anti-HCV seropositive hemophiliacs. Seroprevalence among hemophiliacs was 42.2% (95% CI 36.5-48.1) and was significantly higher (p<0.05) according to age >10 years, presence of factor VIII/IX inhibitory antibodies and other infection markers. None of the hemophiliacs less than 5 years of age were anti-HCV seropositive. Viremia was detectable in 77.3% (51/66). HCV genotype 1 (74%) was the most prevalent followed by genotype 3 (22%) and genotype 2 (4%). Our results indicate that HCV prevalence is still high among hemophiliacs, although HCV transmission was not observed in young hemophiliacs.

【 授权许可】

Unknown