Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis

Revista da Sociedade Brasileira de Medicina Tropical

Elizabeth De Souza Neves²  André Luis Land Curi²  Maira Cavalcanti De Albuquerque¹  Cassius Schnel Palhano-silva¹  Laura Berriel Da Silva²  Wendy Fernandes Bueno²  Maria Regina Dos Reis Amendoeira¹  Maria Da Gloria Bonecini-almeida¹  Octavio Fernandes¹ 

[1] ,Fundação Oswaldo Cruz Instituto de Pesquisa Clinica Evandro Chagas Laboratório de Pesquisa Clínica em Doenças Febris AgudasRio de Janeiro RJ

关键词: Toxoplasmosis;    Interferon gamma;    Retinochoroiditis;    Toxoplasmose;    Interferon-gama;    Retinocoroidite;   

DOI  :  10.1590/S0037-86822012000600020

来源: SciELO

【 摘 要 】

INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.

【 授权许可】

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