Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis

Revista da Sociedade Brasileira de Medicina Tropical

Fernandes, Octavio¹  Amendoeira, Maria Regina dos Reis¹  Escola Nacional de Saúde Pública, Rio de Janeiro¹  Neves, Elizabeth de Souza¹  Albuquerque, Maira Cavalcanti de¹  Silva, Laura Berriel da¹  Bueno, Wendy Fernandes¹  Bonecini-Almeida, Maria da Gloria¹  Curi, André Luis Land¹  Instituto Oswaldo Cruz, Rio de Janeiro¹  Fundação Oswaldo Cruz, Rio de Janeiro¹  Palhano-Silva, Cassius Schnel¹ 

关键词: Toxoplasmosis;    Interferon gamma;    Retinochoroiditis;   

DOI  :  10.1590/S0037-86822012000600020

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis.METHODS: A case-control study was conducted among 30 patients and 90 controls.RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.

【 授权许可】

Unknown