Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a

Revista da Sociedade Brasileira de Medicina Tropical

Ronaldo Soares Martins²  Juliano Antunes Machado²  Rosângela Teixeira¹ 

[1] ,Hospital Felício Rocho Serviço de Gastroenterologia Belo Horizonte MG

关键词: Pegylated interferon alfa-2a;    Bronchiolitis obliterans organizing pneumonia;    Hepatitis C;    Interferon peguilado alfa-2a;    Bronquiolite obliterante com pneumonia organização;    Hepatite C;   

DOI  :  10.1590/S0037-86822012000500023

来源: SciELO

【 摘 要 】

The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon alfa-2a and ribavirin. The lung biopsy confirmed the diagnosis of a bronchiolitis obliterans organizing pneumonia (BOOP). Corticotherapy was initiated, with clinical and radiological improvement. This paper aims to advise physicians to this occasional, though severe, adverse event related to hepatitis C virus (HCV) treatment.

【 授权许可】

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