Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a

Revista da Sociedade Brasileira de Medicina Tropical

Universidade Federal de Minas Gerais, Belo Horizonte¹  Hospital Felício Rocho, Belo Horizonte¹  Machado, Juliano Antunes¹  Martins, Ronaldo Soares¹  Teixeira, Rosângela¹ 

关键词: Pegylated interferon alfa-2a;    Bronchiolitis obliterans organizing pneumonia;    Hepatitis C;   

DOI  :  10.1590/S0037-86822012000500023

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon alfa-2a and ribavirin. The lung biopsy confirmed the diagnosis of a bronchiolitis obliterans organizing pneumonia (BOOP). Corticotherapy was initiated, with clinical and radiological improvement. This paper aims to advise physicians to this occasional, though severe, adverse event related to hepatitis C virus (HCV) treatment.

【 授权许可】

Unknown