Comparative study of survivor and nonsurvivor sepsis patients in a university hospital

Revista da Sociedade Brasileira de Medicina Tropical

Aline Pâmela Vieira De Oliveira²  Cristina Hueb Barata¹  Eddie Fernando Candido Murta¹  Beatriz Martins Tavares-murta² 

[1] ,Federal University of Triângulo Mineiro Department of Biological Sciences Uberaba MG

关键词: Sepsis;    Prognosis;    Antimicrobials;    Risk factors;    Sepse;    Prognóstico;    Antimicrobianos;    Fatores de risco;   

DOI  :  10.1590/S0037-86822008000100010

来源: SciELO

【 摘 要 】

To determine parameters associated with the evolution of sepsis, a five-year retrospective study was conducted in a university hospital. One hundred and four consecutive sepsis patients were evaluated, of whom 55.8% were men. The mortality was 68.3% and was associated with older age (p<0.05). Chronic comorbidities and infection site were not associated with prognosis. Gram-positive bacteria were more frequently identified in survivors (p<0.05), while non-detection of the germ was associated with mortality (p<0.01). Appropriate use of antibiotics (germ sensitive to at least one drug administered) was associated with survival (p<0.0001) while inappropriate use (p<0.05) or empirical use (p<0.01) were more frequent in nonsurvivors. Leukocytosis was the main abnormality (54.8%) detected on diagnosis, from the leukocyte count. During the evolution, normal leukocyte count was associated with survival (p<0.01) and leukocytosis with mortality (p<0.05). In conclusion, mortality was associated with nondetection of the pathogen, leukocytosis during the evolution of the sepsis and inappropriate or empirical use of antimicrobials. Evidence-based treatment that is directed towards modifiable risk factors might improve the prognosis for sepsis patients.

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