Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)

Revista da Sociedade Brasileira de Medicina Tropical

Rozália Figueira Campos¹  Marcos Lázaro S. Guerreiro¹  Karina De Souza Castro Sobral¹  Rita De Cássia P. Cunha Lima¹  Sonia G. Andrade¹ 

[1] ,Fundação Oswaldo Cruz Centro de Pesquisas Gonçalo Moniz Laboratório de Chagas Experimental, Autoimunidade e Imunidade CelularSalvador BA

关键词: Trypanosoma cruzi;    Trypanosoma cruzi II;    Biodeme Type II;    Clones;    Benznidazole;    Chemotherapy;    Trypanosoma cruzi;    Trypanosoma cruzi II;    Biodema Tipo II;    Clones;    Benzonidazol;    Quimioterapia;   

DOI  :  10.1590/S0037-86822005000200003

来源: SciELO

【 摘 要 】

Susceptibility to chemotherapy with benznidazole was investigated of 5 clones isolated from the 21 SF strain (biodeme Type II, Trypanosoma cruzi II). Swiss mice were infected with the parental strain for each clone and submitted to chemotherapy with benznidazole (100mg/kg/day during 90 days). Treatment determined negativity of the parasitemia. Cure rates were evaluated by parasitological cure tests. Serology was evaluated for treated animals (titers from negative to 1:640) and untreated controls (1:160 to 1:640). Cure rates varied from 30 to 100% for the 5 clones, and were 25% for the parental strain. Results suggested that the variability of response to treatment of the clonal populations of Trypanosoma cruzi II strains is responsible for the high variation in the response to chemotherapy with benznidazole and nifurtimox by strains of this biodeme.

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